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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Cancer Treat Rev. 2012 Dec 20;39(6):640–646. doi: 10.1016/j.ctrv.2012.11.006

Figure 1.

Figure 1

A proposed model for PDGF-D signaling pathway that controls the processes of EMT. PDGF-D triggers EMT through regulation of mTOR, Notch, NF-κB, CXCR4, Bcl-2 and microRNAs. Bcl-2: B-cell lymphoma 2; CXCR4: C-X-C chemokine receptor type 4; EMT: Epithelial to mesenchymal transition; mTOR: Mammalian target of rapamycin; NF-κB: Nuclear factor kappa B. PDGF-D: Platelet-derived growth factor-D; S6K: p70 S6 ribosomal kinase; 4E-BP1: the eukaryotic translation initiation factor 4E-binding protein 1.