TABLE 1.
Estimated radiation absorbed doses to an adult human after intravenous injection of 61Cu-NOTA-K3-VEGF121 based on PET imaging data obtained in female mice (n = 4).
| Organ | mGy/MBq (SO) | rad/mCi (SO) |
|---|---|---|
| Adrenals | 2.25E-02 (1.15E-03) | 8.33E-02 (4.24E-03) |
| Brain | 1.54E-04 (1.51E-05) | 5.71E-04 (5.53E-05) |
| Breasts | 4.49E-03 (7.14E-04) | 1.66E-02 (2.63E-03) |
| Gallbladder | 3.28E-02 (1.68E-03) | 1.22E-01 (6.35E-03) |
| LLI Wall | 5.08E-03 (2.34E-03) | 1.88E-02 (8.64E-03) |
| Small Intestine | 6.93E-02 (4.28E-02) | 2.57E-01 (1.59E-01) |
| Stomach | 9.88E-03 (2.60E-04) | 3.66E-02 (9.95E-04) |
| ULI Wall | 1.62E-02 (4.96E-03) | 5.98E-02 (1.83E-02) |
| Heart | 6.33E-02 (2.52E-02) | 2.34E-01 (9.33E-02) |
| Kidneys | 2.04E-01 (8.68E-03) | 7.54E-01 (3.29E-02) |
| Liver | 2.29E-01 (2.17E-02) | 8.47E-01 (8.07E-02) |
| Lungs | 1.03E-02 (1.41E-03) | 3.82E-02 (5.21E-03) |
| Muscle | 5.43E-03 (1.55E-04) | 2.01E-02 (5.89E-04) |
| Ovaries | 7.67E-03 (3.42E-03) | 2.84E-02 (1.27E-02) |
| Pancreas | 1.85E-02 (9.11E-04) | 6.83E-02 (3.44E-03) |
| Skin | 6.11E-03 (3.72E-04) | 2.26E-02 (1.37E-03) |
| Spleen | 4.30E-03 (1.03E-04) | 1.59E-02 (3.74E-04) |
| Thymus | 2.46E-03 (7.75E-05) | 9.10E-03 (2.74E-04) |
| Thyroid | 1.02E-02 (1.70E-04) | 3.77E-02 (6.50E-04) |
| Urinary | 6.27E-03 (1.72E-03) | 2.32E-02 (6.35E-03) |
| Uterus | 1.01E-03 (1.45E-04) | 3.72E-03 (5.35E-04) |
| Effective dose | 2.42E-02 (1.04E-03) | 8.96E-02 (3.14E-03) |
LLI = lower large intestine; ULI = upper large intestine.