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. Author manuscript; available in PMC: 2014 Jun 20.
Published in final edited form as: Eur J Pharm Sci. 2012 Dec 20;48(3):416–427. doi: 10.1016/j.ejps.2012.12.006

Figure 4.

Figure 4

In vivo fluorescence imaging of nude mice bearing intracranial U87 MG glioma tumors after an intravenous injection of nanoparticles either (a) conjugated with Angiopep or (b) left bare. (c) Images of dissected organs from U87 MG glioma tumor-bearing mice, removed 24 hours after an injection of nanoparticles. We observe a collection of nanoparticles both at the tumor site in the brain (indicated by the arrows) and in the MPS/RES organs such as the liver and spleen. (d) TEM image of the PEG-PCL nanoparticles. (e) TEM image of the PEG-PCL nanoparticles after modification with Angiopep (Xin et al., 2011).