Table 3. Polymorphism results in univariate and multivariate analyses.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
|
Polymorphism |
Genotype |
No. of patients |
PFS |
OS |
PFS |
OS |
|
VEGF A |
|
|
|
|
|
|
| rs833061 |
CC+CT |
60 |
|
|
|
|
| |
TT |
24 |
|
|
|
|
| |
|
|
P<0.0001 |
P<0.0001 |
P=0.0197 |
P=0.0011 |
| |
|
|
|
|
HR=0.71 |
HR=0.69 |
| rs2010963 |
CC |
8 |
|
|
|
|
| |
CG |
39 |
|
|
|
|
| |
GG |
37 |
|
|
|
|
| |
|
|
P=0.0001 |
P=0.0045 |
P=0.0201 |
P=0.5932 |
| |
|
|
|
|
HR=0.19 |
HR=0.24 |
| rs699947 |
AA+AC |
60 |
|
|
|
|
| |
CC |
24 |
|
|
|
|
| |
|
|
P=0.0001 |
P<0.0001 |
P=0.9801 |
P=0.5856 |
| |
|
|
|
|
HR=0.69 |
HR=0.65 |
|
VEGFR3 |
|
|
|
|
|
|
| rs6877011 |
CC |
71 |
|
|
|
|
| |
CG |
13 |
|
|
|
|
| |
GG |
0 |
|
|
|
|
| |
|
|
P=0.0075 |
P=0.0001 |
P<0.0001 |
P<0.0001 |
| HR=0.35 | HR=0.39 | |||||
Abbreviations: HR=hazard ratio; OS= overall survival; PFS=progression-free survival; VEGF=vascular endothelial growth factor; VEGFR3=VEGF receptor 3.