Table 5. Predictors of anxiety, depression, intrusion, avoidance or perceived personal control at BRCA1/2 test result notification consultation (final model β).
| HADS-Anxiety | HADS-Depression | IES-Intrusion | IES-Avoidance | Perceived Personal Control | |
|---|---|---|---|---|---|
| Score at T1 |
0.46*** |
0.50*** |
0.41*** |
0.43*** |
0.45*** |
| Age |
−0.00 |
−0.11 |
−0.05 |
−0.08 |
0.09 |
| Education |
0.06 |
0.07 |
−0.10 |
−0.05 |
−0.04 |
| Having a partner |
0.03 |
−0.02 |
0.03 |
0.01 |
−0.06 |
| Having daughters |
0.11 |
0.07 |
0.00 |
−0.10 |
−0.04 |
| Under treatment (vs in remission) |
0.17* |
0.02 |
0.13 |
0.13 |
0.04 |
| Relatives diagnosed of breast or ovarian cancer <50 years old |
−0.00 |
0.03 |
−0.05 |
−0.08 |
0.05 |
| Lapse of time between initial and second genetic consultation |
0.09 |
−0.02 |
0.13 |
0.21** |
0.03 |
| BC risk perception at T2 |
0.04 |
0.07 |
−0.11 |
−0.11 |
−0.04 |
| OC risk perception at T2 |
0.16* |
0.12 |
0.16 |
0.16 |
−0.17* |
| Perceived probability of genetic predisposition |
−0.01 |
−0.03 |
0.04 |
0.00 |
−0.08 |
| Objective estimates vs perceived probability of genetic predisposition difference |
−0.05 |
−0.12 |
0.01 |
0.14 |
0.13 |
| Block 1 (control variables): F(df); R2; Adjusted R2 |
5.06 (148,12)***0.29; 0.23 |
5.22 (148,12)***0.30; 0.24 |
4.18 (148,12)***0.25; 0.19 |
5.26 (148,12)***0.30; 0.24 |
5.60 (148,12)***0.31; 0.26 |
| Positive BRCA (vs NU) | 0.31** | 0.14 | 0.21* | 0.02 | 0.05 |
| UV (vs NU) |
0.03 |
−0.00 |
0.14* |
0.05 |
0.03 |
| Block 2 (+ BRCA1/2 test result): F change(df); R2change; Adjusted R2 |
1.26 (146,2);0.01; 0.24 |
0.32 (146,2);0.003; 0.23 |
2.68 (146,2);0.03; 0.21 |
0.33 (146,2);0.003; 0.24 |
1.30 (146,2);0.01; 0.26 |
| Objective vs perceived probability of genetic predisposition difference × positive BRCA | −0.28** | −0.09 | −0.10 | −0.04 | 0.12 |
| Objective vs perceived probability of genetic predisposition difference × UV |
0.20** |
0.19* |
0.18* |
−0.05 |
0.02 |
| Block 3 (+ interactions): F change(df); R2change; Adjusted R2 | 8.18 (144,2)*** 0.07; 0.30 | 3.64 (144,2)*0.03; 0.26 | 3.2 (144,2)*0.03; 0.23 | 0.21 (144,2);0.002; 0.23 | 0.68 (144,2);0.01; 0.26 |
Abbreviations: BC=breast cancer; HADS=Hospital Anxiety and Depression Scale; IES=Impact of Event Scale; OC=ovarian cancer; UV=unclassified variant. *P<0.05; **P<0.01; ***P<0.001.