Table 2. Expression pattern of biomarkers in early operable primary beast cancer – young (<70 years) vs older (⩾70 years) women.
|
Categorical variables <70
vs
⩾70 years |
|||
|---|---|---|---|
| Biomarker | <70 N (%) | ⩾70 N (%) | P-value |
| ER | 0.04 | ||
| Positive | 953 (66.7) | 401 (70.1) | |
| Negative | 476 (33.3) | 171 (29. 9) | |
| PgR | 0.08 | ||
| Positive | 1005 (58.9) | 317 (55.5) | |
| Negative | 702 (41.1) | 254 (44.5) | |
| HER2 | 0.40 | ||
| Positive | 140 (8.2) | 45 (7.7) | |
| Negative | 1574 (91.8) | 538 (92.3) | |
| CK5 | <0.001 | ||
| Positive | 204 (15.8) | 155 (29.9) | |
| Negative | 1086 (84.2) | 364 (70.1) | |
| CK5/6 | <0.001 | ||
| Positive | 288 (16.7) | 194 (35.0) | |
| Negative | 1432 (83.3) | 360 (65.0) | |
| CK7/8 | 0.001 | ||
| Positive | 1717 (99.1) | 548 (97.2) | |
| Negative | 15 (0.9) | 16 (2.8) | |
| CK18 | <0.001 | ||
| Positive | 1453 (89.4) | 527 (95.6) | |
| Negative | 172 (10.6) | 24 (4.4) | |
| CK19 | 0.46 | ||
| Positive | 1633 (94.4) | 533 (94.7) | |
| Negative | 96 (5.6) | 30 (5.3) | |
| Muc1 | 0.05 | ||
| Positive | 1258 (89.4) | 510 (91.9) | |
| Negative | 149 (10.6) | 45 (8.1) | |
| E-cadherin | <0.001 | ||
| Positive | 1458 (84.8) | 421 (73.9) | |
| Negative | 261 (15.2) | 149 (26.1) | |
| p53 | <0.001 | ||
| Positive | 468 (27.4) | 199 (35.7) | |
| Negative | 1241 (72.6) | 359 (64.3) | |
| Bcl2 | <0.001 | ||
| Positive | 301 (43.8) | 441 (82.7) | |
| Negative | 387 (56.3) | 92 (17.3) | |