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Model for stabilisation of p53 through a formation of p28 : p53 complex. p28 binds to a specific motif within the p53 DNA-binding domain that inhibits p53 proteasomal degradation and stabilizes p53, independently of HDM2. The increase in p53 transcriptionally regulates downstream genes, p21, p27, leading to inhibition of the cancer cell cycle at G2/M.
