Table 2. Patient disease and prior treatment.
| Survival in weeks | Prior treatment | p28 dose levels received | Disease at study entry |
|---|---|---|---|
| 158 (Alive) |
Refused |
2,3,4,5 |
Melanoma— left flank and lung nodules. Stage IV (M1b) |
| 140 (Alive) |
Allovectin-7; GP100 T-cell receptor clinical trial; IL-2; MART-I-F5 TCR clinical trial; RT to posterior neck and base of the occipital for loco-regional recurrence (4500 Gy, 250 Gy per session) |
3,4,5 |
Left post. Neck lesion; left post-nuchal lymphadenopathy. Stage III (unresectable) |
| 110 (Alive) |
Xeloda/Irinotecan; FOLFOX/Avastin; FOLFIRI/Avastin; Avastin/Erbitux; 5-FU/Leucovorin |
5 |
Multiple lung mets; retroperitoneal lymphadenopathy. Stage IV |
| 71 |
RT, external beam; Vectibix; Xeloda; Irinotecan; Irinotecan/Exurbia; FOLFIRI/Avastin; FOLFOX |
3,4,5 |
Bilateral lung mets; pelvic mass. Stage IV |
| 44 |
Refused |
4,5 |
Metastatic melanoma— lung. Stage IV |
| 32 |
DTIC |
2,3 |
Multiple dermal (subcutaneous) mets; left axillary LN's, liver lesion (right lobe). Stage IV |
| 32 |
High-dose IFN; DTIC, BCNU, Tamoxifen, IL-2; adjuvant biochemo; Biochemo |
2,3,4,5 |
Multiple liver mets, abdominal and sacral masses. Stage IV |
| 28 |
Nexavar; RT to sacrum; Lupron; Ketoconazole, OEstrogen patch, Leukine initiated; Docetaxel/Bevacizumab; Carboplatin/Etoposide |
4,5a |
Hepatic mets, multiple bone mets. Stage IV |
| 20 |
RT to right chest and axilla |
5 |
Multiple dermal/SC mets; liver and spleen. Stage IV |
| 17 |
Taxotere and Gemzar (2006); Taxotere/Gemzar (2008); RT pelvis |
1,2,3b |
Multiple lung mets, large abdominal mass and midline rectus muscle mass. Stage IV |
| 12 |
RT; 5-FU/Leucovorin; Erbitux; FOLFIRI/bevacizumab, CPT-11; S/P radiofrequency ablation; Rapamycin/grapefruit juice; FOLFOX/Bevacizumab |
1 |
Multiple lung mets. Stage IV |
| 12 |
Elesclomol clinical trial; DTIC; Taxol |
3 |
Multiple lung and liver mets; bone, abd/pelvis LN's. Stage IV |
| 10 |
Ifosfamide, Mesna, and Etoposide; S/P extensive resection; Gleevec; Vincristine/Adriamycin/Cytoxa; Sutent |
5 |
Leiomyosarcoma omentum and mesentery; GIST Stage IV unresectable |
| 7 |
Avastin; Vectibix; Rituxan; Oxaliplatin; Erbitux; CPT-11/5-FU/Leucovorin; CPT-11; Camptosar/5-FU/Leucovorin |
1 |
Multiple lung mets and large right hilar mass. Stage IV metastatic colon cancer |
| 7 | Gemcitabine and Tarceva; Xeloda/Oxaliplatin; Xeloda/Tarceva | 4 | Pulmonary, liver, and head of pancreas. Stage IV |
Abbreviations: 5-FU=fluorouracil; BCNU=Carmustine; CPT-11=Irinotecan; DTIC=Dacarbazine; FOLFIRI=FOL-folinic acid (leucovorin) and F-fluorouracil (5-FU) and IRI-irinotecan (Camptosar); FOLFOX=FOL-Folinic acid (leucovorin) and F-Fluorouracil (5-FU) and OX-Oxaliplatin (Eloxatin); IFN=interferon; RT=radiation therapy.
a
Completed 10 out of 12 doses.
b
Completed 9 out of 12 doses.