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. 2013 Apr 3;10(6):676–682. doi: 10.7150/ijms.5528

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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miR-34a inhibits the proliferation of osteosarcoma cells. A: The proliferation of osteosarcoma cells was determined by CCK-8 assay at 24, 48, 72, and 96 h after transfection of miR-34a into MG-63 and Saos-2. The proliferation of osteosarcoma cells was significantly reduced after transfection wtih miR-34a. Data were presented as mean ± SD (n = 6). B: The tumorigenicity of osteosarcoma cells was determined by colony formation assay. The tumorigenicity of osteosarcoma cells was significantly reduced after transfection wtih miR-34a. Data were presented as mean ± SD (n = 3). ** P<0.01, *** P<0.001.