FIG. 4.

Silencing efficiency of the cSCK nanoparticles compared with Lipofectamine 2000. The silencing efficiency was calculated as the difference between the survival rate (%) of cells transfected with the AllStars Negative Control siRNA, and the survival rate (%) of the AllStars Cell Death Control siRNA using the lethal concentration 50 (LC₅₀) and Hill slope coefficients derived from the raw data. (A) The silencing efficiency for PAEA₁₂₈-b-PS₄₀ derived cSCKs with different shell compositions in HeLa derived from the data in Supplementary Table S1, and (B) for silencing in different cell lines with PAEA₁₆₀-b-PS₃₀ cSCK-pa₁₀₀ using data in Supplementary Table S2 (Supplementary Data are available online at www.liebertpub.com/nat).