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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Neurobiol Aging. 2012 Dec 29;34(6):1530–1539. doi: 10.1016/j.neurobiolaging.2012.11.023

Fig. 1.

Fig. 1

Experimental design and body weight of mice during the course of the dietary intervention. (A) To characterize the behavioral effects of the ketone ester on 3xTgAD mice, we developed a strategy to analyze the cognitive performance of the mice at 12 months (phase 1) and at 15 months (phase 2). The dietary intervention was started at 8.5 months with initiation of either a carbohydrate-enriched (CHO) or a ketone ester (KET) diet. The mice were euthanized at the age of 16.5 months after completion of all behavioral testing for phase 2. (B) Body weight of 3xTgAD mice in the CHO and KET diet groups during the course of the study. Values are the mean and SEM (n = 11–15 mice per group).