Ketone ester-fed 3xTgAD mice exhibit greater exploratory activity in the open field test. (A) Total distance traveled (cm) in phases 1 and 2. (B) Total ambulatory time (seconds) in phases 1 and 2. (C) Total ambulatory counts in phases 1 and 2. (D, E, and F) Distance traveled (D), ambulatory time (E), and ambulatory counts (F) in the open area. (G) Examples of the paths of individual mice in the open field in phase 2 tests. Values are the means and SEM (n = 10–14 mice per group) *p < 0.05 by t test. #p < 0.05 by two-way ANOVARM. CHO, carbohydrate-enriched diet; KET, ketone ester diet.