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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Neurobiol Aging. 2012 Dec 29;34(6):1530–1539. doi: 10.1016/j.neurobiolaging.2012.11.023

Fig. 4.

Fig. 4

A ketone ester (KET) diet improves the performance of 3xTgAD mice in hippocampus-dependent water maze tests of spatial memory. (A, B) Results for goal latencies for memory acquisition trials (hidden platform) and reversal trials in phase 1 (12 months) and phase 2 (15 month) tests. The results of the working memory tests in phase 2 are also shown. Performance in the KET group proved significant using two-way ANOVARM measures analysis for phase 1 in Hidden and Reverse (p = 0.040) and Reverse alone (p = 0.026). For phase 2, significance was demonstrated for Hidden, Reverse, and Working (p = 0.018). Values are mean and SEM (n = 10–14).