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. Author manuscript; available in PMC: 2013 Apr 8.
Published in final edited form as: Dev Biol. 2011 Jun 25;357(1):227–234. doi: 10.1016/j.ydbio.2011.06.027

Figure 7. Shroom3 and a Pitx2-N-cadherin pathway function cooperatively to generate asymmetric cell shape changes during gut morphogenesis.

Figure 7

The model illustrates the proposed mechanism where Shroom3 regulates cell shape specifically in the left dorsal mesentery downstream of Pitx2. The Pitx2 regulation of Shroom3 activity is achieved by directing asymmetric, leftward N-cadherin expression. The elongation and apical constriction of left epithelial dorsal mesentery cells together with asymmetrical mesenchymal packing causes leftward tilting biasing the direction of gut coiling.