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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2012 May 10;32(7):1624–1631. doi: 10.1161/ATVBAHA.112.246066

Figure 3. LXR modulation of fecal neutral sterol excretion, cholesterol absorption and efflux in control and MTTP-IKO mice.

Figure 3

(A). Fecal neutral sterol excretion was quantified (SUPPLEMENTAL METHODS) from samples obtained in 7–13 mice per group both at baseline and following LXR administration. (B). Cholesterol absorption was measured by the dual fecal isotope ratio method in the same groups (n=7 per group) as above. (C). Mice (4–5 per group) were administered an intravenous bolus of 3H cholesterol and serum cholesterol specific activity determined at the indicated intervals over the following 5 days. (B). Stool was collected from each of the animals in the groups above and samples saponified and extracted (SUPPLEMENTAL METHODS) for quantification of both radiolabeled neutral sterol (B) and bile acid (C) species. Symbols * and ** indicate p<0.05 or <0.01, respectively.