Table 2.
A) INTESTINAL MUCOSA
| ||||||
---|---|---|---|---|---|---|
Genotype | TG | TC | FC | CE | PL | FFA |
Control-V | 66.2±7.4a | 49.7±7.4a | 45.5±5.2a | 4.3±2.3a | 88.1±2.2a | 25.11±1.96a |
Control-T | 74.0±14.5a | 55.0±5.2a | 46.9±3.3a | 8.1±2.2a | 102.4±5.9a | 45.5±17.7a |
MttpIKO-V | 704.9±80.9b | 76.1±5b | 51.4±1.6a | 27.7±3.8b | 149.8±9.6b | 192.8±43.1b |
MttpIKO-T | 704.6±45.9b | 78.5±8.1b | 55.3±4.7a | 23.2±3.6b | 169.5±9.3b | 159.2±22.1b |
B). HEPATIC
| ||||||
---|---|---|---|---|---|---|
Genotype | TG | TC | FC | CE | PL | FFA |
Control-V | 71.3±10.3a | 27.3±1.1a | 10.7±1.3a | 16.6±1.9a | 99.1±5.5a | 0.17±0.01a |
Control-T | 260.4±18.5b | 17.6±1.9b | 11.4±1.3a | 6.1±0.9b | 105.7±4.5a | 0.34±0.03b |
MttpIKO-V | 39.5±6.3c | 21.9±1.1b | 9.6±1.3a | 12.4±1.6ab | 94.1±8.3a | 0.14±0.01a |
MttpIKO-T | 246.7±21.7b | 19.3±1.7b | 9.1±0.8a | 10.2±1.8ab | 103.4±3.4a | 0.27±0.02b |
Control and MttpIKO mice (n=6–11) were treated either vehicle (V) or T0901317 (T). Tissue total cholesterol (TC), free cholesterol (FC), phospholipids (PL), and triglyceride (TG) were analyzed (Methods). Hepatic (A) and mucosal (B) lipid content was expressed as mean ±SE ug/mg protein, except FFA nmol/mg protein. The difference between values associated with different superscript letters for the parameters indicated in each vertical column is statistically significant (p<0.05).