Table 3.
Flow rate | Cholesterol | Phospholipids | Bile acid | |
---|---|---|---|---|
Control-V | 42.4±4.3a | 24.2±2.9a | 246.9±23.4a | 1455.3±362.6a |
Control-T | 86.8±16.0b | 74.4±17.9b | 251.2±31.9a | 2069.6±94.8a |
MttpIKO-V | 88.2±4.6b | 104.6±17.3b | 315.1±26.7a | 2101.8±414.6a |
MttpIKO-T | 86.4±7.6b | 92.98±6.1b | 235.4±12.6a | 2550.2±301.8a |
Control and MttpIKO mice (n=7–17) were treated either vehicle (V) or T0901317 (T) for 7 days. Bile samples were collected for 1 hour. The flow rate was expressed as μl/min/kg body weight. Biliary cholesterol, phospholipids and bile acids were analyzed (Methods). Biliary lipid secretion was expressed as nmol/min/Kg body weight. The difference between values associated with different superscript letters for the parameters indicated in each vertical column is statistically significant (p<0.05).