Figure 6.

Coregistered images of fluorescence intensity data (in arbitrary units) collected from a healthy subject with an ICG-filled target using the initial set-up (subject seated in upright position). (A) Location of probe and coregistered image relative to the subject for Case #1. (B) Zoomed image for Case#1: 0.45 cm³ target at the 6 o’clock position. (C) Case #2 image: 0.45 cm³ target at the 4 o’clock position. (D) Case #3 image: 0.23 cm³ target at the 8 o’clock position. All targets contain 1 μM ICG (in 1% Liposyn solution). The yellow dotted line was overlaid to estimate the probe location (not to scale). The images show the fluorescence intensity coregistered to the location of the probe (source and detector positions) with respect to the (discretized) scanned tissue geometry. Subtraction was used prior to coregistration to remove background noise in all cases.