Fig. 5.

Biological classifications of nominated gene candidates. (A) The network map using ingenuity pathway analysis shows interactions between the core biogenesis proteins and the nominated genes. Identified core components of miRNA biogenesis are bolded in red. Reported miRNA biogenesis components that were inactive are bolded in black. The nonessential genes are depicted in blue and essential genes are depicted in green. (B) Top four core gene clusters found in nonessential genes. The ranking of each cluster is based on a statistical score from MCODE.