Table 1. Reported reactivities of commercially available crossreactive anti-LPS mAbs used in these studies.
mAb | LPS specificity | Species | Isotype |
---|---|---|---|
15306 | Shigella sonnei Salmonella typhimurium Serratia marcescens Proteus mirabilis Proteus vulgaris Acinetobacter calcoaceticus | Mouse | IgG2a |
15308 | Enterobacter aerogenes Serratia marcescens Proteus mirabilis Acinetobacter calcoaceticus Pseudomonas aeruginosa | Mouse | IgG3 |
15174 | Chlamydia trachomatis | Mouse | IgG2a |
Antibodies were assessed by ELISA for binding to purified LPS. LPS of Chlamydia trachomatis lacks the O-polysaccharide region most distal to lipid A. Thus, although being marketed as anti-Chlamydia antibody, mAb 15174 was chosen for its potential reactivity towards conserved core regions of LPS.