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Working Model: USP7/Daxx regulation of mitosis and taxane resistance. Daxx activates USP7 for deubiquitination of mitotic E3 ligase CHFR; stabilization of CHFR elevates Aurora-A ubiquitination and degradation. Deregulation of USP7 or Daxx reduces stability of CHFR, accumulation of Aurora-A (and multipolar mitosis), stabilization of cyclin B, blocking cells in mitosis and prompting survival of cells following taxanes treatment. Ub: ubiquitin
