Figure 6.
Depletion of CD8 T cells abrogates tumour regression after induction of the death switch. C57Bl/6 mice were inoculated with 1 × 106 death switch cells s.c. on the right flank and the effect of CD8 depletion on death switch induction (dox, 0.2 ml, 10 μg/ml p.o.) on tumour growth measured over time. (a) Depletion of CD8-positive cells in peripheral blood was confirmed by flow cytometry. (b) Mean tumour volume 7 days after treatment, and (c) Kaplan–Meier survival curve survival plot of mice given vehicle control or dox in the presence or absence of CD8-depleting antibody. **P<0.01. Data are representative of at least two individual experiments