Table 2. Multivariate analysis using the stepwise Cox regression procedures.

	Univariatea	Multivariateb
Variables	P-value	HR	95% CI	P-value
Sex
Male vs female	0.8064	2.673	1.098–6.504	0.0302
Age
⩾60 vs <60	0.0243	2.841	1.121–7.194	0.0277
Location
U vs ML	0.0370		—
Histological type
Undifferentiated vs differentiated	0.9078		—
Tumour size (mm)
⩾35 vs <35	<0.0001		—
Venous invasion
Positive vs negative	<0.0001	2.865	1.183–6.944	0.0195
Lymphatic invasion
Positive vs negative	<0.0001		—
pT-stage
T3–4 vs T1–2	<0.0001	20.833	2.577–166.667	0.0044
pN-stage
N2-3 vs N0-1	<0.0001	7.692	2.770–21.28	<0.0001
YWHAZ expression
High vs low	0.0190	2.307	1.003–5.304	0.0491

Abbreviations: CI=confidence interval; HR=hazard ratio.

Note: significant values are in boldface type.

^aThe Kaplan–Meier method, and significance was determined by log-rank test.

^bMultivariate survival analysis was performed using Cox proportional hazard model.