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. 2013 Jan 29;108(6):1378–1386. doi: 10.1038/bjc.2013.7

Table 3. Gene-based P-values for 9p21.3 genes in association with eight tumour outcomesa.

Geneb
 Renal cell carcinoma
 Endometrial cancer
 Thyroid cancer
 Colorectal cancer
 Colorectal adenoma
 Oesophageal squamous cell carcinoma
 Gastric cardia adenocarcinoma
 Osteosarcoma
  (473/1603)c (417/407) (344/452) (393/434) (1234/1368) (1027/1452) (753/1452) (96/1426)
IFNB1
 0.15
 0.94
 0.74
 0.79
 0.39
 0.27
 0.91
 0.99
IFNW1
 0.62
 0.63
 0.56
 0.06
 0.68
 0.82
 0.3
 0.97
IFNA21
 0.65
 0.65
 0.97
 0.78
 0.28
 0.78
 0.9
 0.74
IFNA10
 0.51
 0.76
 0.8
 0.88
 0.07
 0.87
 0.26
 0.9
IFNA16
 0.42
 0.71
 0.35
 0.53
 0.29
 0.95
 0.05
 0.52
IFNA17
 0.58
 0.95
 0.99
 0.28
 0.78
 0.32
 0.86
 0.89
IFNA14
 0.4
 0.47
 0.66
 0.98
 0.51
 0.7
 0.56
 0.65
IFNA5
 0.61
 0.88
 0.82
 0.48
 0.08
 0.77
 0.22
 0.17
KLHL9
 0.31
 0.7
 0.45
 0.46
 0.038
 0.68
 0.16
 0.75
IFNA6
 0.4
 0.57
 0.51
 0.74
 0.026
 0.56
 0.32
 0.81
IFNA2
 0.75
 0.11
 0.73
 0.87
 0.1
 0.66
 0.38
 0.89
IFNA8
 0.76
 0.65
 0.88
 0.94
 0.19
 0.26
 0.31
 0.6
IFNA1
 0.23
 0.66
 1
 0.99
 0.14
 0.18
 0.56
 0.65
IFNE1
 0.07
 0.14
 0.53
 0.29
 0.37
 0.89
 0.25
 0.57
MTAP
 0.37
 0.12
 0.76
 0.31
 0.006
 0.015
 0.52
 0.63
CDKN2A
 0.88
 0.32
 0.65
 0.47
 0.77
 0.0001d
 0.43
 0.19
CDKN2B
 0.35
 0.02
 0.26
 0.54
 0.41
 0.01
 0.67
 0.21
CDKN2BAS
 0.99
 0.04
 0.07
 0.44
 0.45
 0.009
 0.84
 0.43
TUSC1
 0.75
 0.77
 0.18
 0.14
 0.1
 0.19
 0.79
 0.32
PLAA
 0.98
 0.73
 0.21
 0.46
 0.58
 0.36
 0.88
 0.64
IFNK
 0.07
 0.82
 0.6
 0.92
 0.3
 0.84
 0.49
 0.86
ACO1 0.46 0.73 0.27 0.14 0.74 0.53 0.3 0.44
a

Gene-based P values were computed using the minP method, based on 10 000 permutations; P-value⩽0.01 was shown in boldface.

b

Genes are ordered by location from telomere to centromere.

c

Number of cases and controls.

d

Significant after Bonferroni correction for number of genes and studies (0.05/(22 × 8)=2.8 × 10−4).