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. 2013 Mar 19;110(14):5468–5473. doi: 10.1073/pnas.1219476110

Fig. 3.

Fig. 3.

Representative cryo-EM images of averaged fibrils (class averages), surface representations of reconstructions, 2D projections, and contoured density cross-sections of the three types of fibril formed by TTR(105–115). (A) Doublet class average (Left), 3D reconstruction (Center; orange), and 2D projection of the fibril reconstruction (Right). (B) Triplet class average (Left), 3D reconstruction (Center; yellow), and 2D projection of the fibril reconstruction (Right). (C) Quadruplet class average (Left), 3D reconstruction (Center; purple), and 2D projection of the fibril reconstruction (Right). (D–F) Contoured density cross-sections of the doublet (D), triplet (E), and quadruplet (F) fibrils. Contours represent density levels of multiples of 0.5σ above the average density of the background (outermost contour). Measurements of dimensions were determined at 1.0σ above the mean density.