Fig. 1.

TPPU prevents the development of cardiac hypertrophy in a murine myocardial infarction (MI) model. (A) Structure of the sEHI, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl) urea (TPPU) used in our studies. (B) Schematic representation of the experimental protocol. (C) Examples of whole hearts from sham-operated, TPPU-treated–sham-operated, MI, and TPPU-treated MI mice. Mice were killed after 3 wk of follow-up. (Scale bar, 2 mm.) (D) Summary data for heart weight (in milligrams), and (E) heart weight/body weight ratio (percentage) from MI mice compared with untreated MI mice. Error bars represent SE, n = 12 per group, and ^§P < 0.05 by Student t test.