Figure 1.
Adenylyl Cyclases as Examples of a Junction
The signal receiving capabilities of the various adenylyl cyclase isoforms and the capability of the cAMP-dependent protein kinase (PKA) to regulate various physiological functions are shown. Receptor channel, ligand gated channel (e.g., NMDA receptor); RTK, receptor tyrosine kinase; GPCR, G protein–coupled receptor. Stimulatory signals are shown as arrows and inhibitory signals as plungers. The various cellular components or processes regulated by PKA are shown in the red ovals and the resultant physiological functions are given below.