Table 1.
Intracellular Feedback Inhibitors of Inflammation
| Inhibitor | Function | Reference |
|---|---|---|
| Tristetraprolin (TTP) | Promotes degradation of transcripts encoding proinflammatory cytokines |
(Carballo et al. 1998) |
| Suppressor of Cytokine Signaling-3 (SOCS3) |
Blocks activation of Janus kinases/signal transducers and activators of transcription (JAK/STAT) |
(Cacalano et al. 2001) |
| IL-1 Receptor- associated Kinase M (IRAK-M) |
Inhibits function of IL-1 receptor-associated kinase (IRAK), inhibits IL-1 and TLR signal transduction |
(Kobayashi et al. 2002) |
| Toll-interacting Protein (TOLLIP) |
Binds to and sequesters IRAK, inhibits IL-1 and TLR signal transduction |
(Zhang and Ghosh 2002) |