Figure 2.

Influence of inhibitors on ³H-digoxin binding in isolated nerve cords: (a) effect of the metabolic inhibitors 2,4-DNP and CCCP on nerve cords of M. sexta (n = 5; mean±s.d.). (b) Effect of the PGP inhibitors quinidine and verapamil on nerve cords of M. sexta (n = 5; mean±s.d.). (c) Influence of the metabolic inhibitor CCCP and the PGP inhibitor verapamil on ³H-digoxin binding in isolated nerve cords of D. nerii (n = 6; mean±s.d.). Asterisks above horizontal lines indicate significant differences (p < 0.05, randomized block ANOVA with experiment as blocking factor, followed by Tukey HSD tests). Each data point represents the mean of 5 nerve cords per treatment (b and c) or 6 nerve cords per treatment (c) ±s.d.