Table III. Top five unique IPA functions enriched in targets of differentially expressed high-abundance miRNAs between DA and PVG.
| Category | p Value | No. of Molecules* | Representative Subgroups | p Value | No. of Molecules |
|---|---|---|---|---|---|
| DA | |||||
| Cellular movement | 8.16E-06–1.78E-02 | 28 (CXCR3, STAT1) | Migration of cells | 2.90E-05 | 13 |
| Cell movement of leukocytes | 5.13E-04 | 25 | |||
| Amino acid metabolism | 1.05E-04–1.64E-02 | 12 (PRKCD) | Accumulation of neutral amino acid | 1.05E-05 | 2 |
| Transport of D-serine | 2.09E-04 | 2 | |||
| Cellular function and maintenance | 1.31E-04–1.78E-02 | 18 (CXCR3, PRKCD, STAT1) | Compartmentalization of cells | 1.31E-04 | 3 |
| Influx of Ca2+ | 1.97E-03 | 5 | |||
| Cellular development | 1.37E-04–1.78E-02 | 31 (PRKCD, STAT1) | Differentiation of cells | 3.35E-04 | 24 |
| Growth of tumor cells | 1.07E-03 | 6 | |||
| Cell-to-cell signaling and interaction | 2.14E-04–1.78E-02 | 26 (CXCR3, STAT1) | adhesion of immune cells | 2.14E-04 | 9 |
| Chemoattraction of mononuclear leukocytes | 4.29E-04 | 3 | |||
|
p Value |
No. of Molecules |
Function Annotation |
p Value |
No. of Molecules |
|
| PVG | |||||
| Cellular development | 7.64E-05–4.21E-02 | 19 | Differentiation of cells | 5.75E-05 | 16 |
| Developmental process of B lymphocytes | 7.00E-03 | 4 | |||
| Gene expression | 5.24E-05–3.96E-02 | 19 | Transcription of RNA | 5.24E-05 | 17 |
| Expression of RNA | 5.48E-05 | 18 | |||
| Cell death | 6.83E-05–4.21E-02 | 18 | Cell death of organ | 6.83E-05 | 11 |
| Apoptosis of tumor cell lines | 1.78E-03 | 10 | |||
| Cellular growth and proliferation | 7.99E-05–3.6E6-02 | 9 | Inhibition of cancer cells | 7.99E-05 | 2 |
| Generation of B-1a lymphocytes | 5.72E-03 | 1 | |||
| Lipid metabolism | 4.35E-04–3.66E-02 | 4 | Esterification of fatty acid | 4.35E-04 | 2 |
| Biosynthesis of phosphatidylglycerol | 2.86E-03 | 1 |
*
miRNA target genes in parentheses were used in in vitro studies.