Table III. Gene ontology of DMR-associated genes.

Best GO	Category	Count	Total	p Valuea
Hypomethylated in memory T cells
GO:0007154	Cell communication	119	5560	3.49E−18
GO:0007165	Signal transduction	111	5142	2.65E−17
GO:0007242	Intracellular signaling pathway	55	1965	4.94E−14
GO:0007267	Cell–cell signaling	25	640	5.25E−11
GO:0032502	Developmental process	69	3347	1.20E−08
GO:0007275	Multicellular organismal development	53	2299	1.20E−08
GO:0032501	Multicellular organismal process	75	3822	2.33E−08
GO:0048731	System development	39	1605	5.67E−07
GO:0065007	Biological regulation	109	6731	7.44E−07
GO:0050789	Regulation of biological process	101	6140	1.22E−06
GO:0007215	Glutamate signaling pathway	6	21	3.93E−06
GO:0048519	Negative regulation of biological process	30	1182	7.67E−06
GO:0048856	Anatomical structure development	43	2005	8.94E−06
GO:0009966	Regulation of signal transduction	23	800	8.94E−06
GO:0048523	Negative regulation of cellular process	29	1137	8.96E−06
Hypomethylated in memory T cells
GO:0032502	Developmental process	19	3347	4.57E−06
GO:0065007	Biological regulation	29	6731	4.57E−06
GO:0050789	Regulation of biological process	27	6140	6.68E−06
GO:0016070	RNA metabolic process	21	4155	8.43E−06

^aEach category was based on a p value < 1.0E−05.