Table V. Gene-expression profile of effector and memory CD4+ T cells compared with naive CD4+ T cells.
| No. of Tags in |
RefSeq | Description | ||
|---|---|---|---|---|
| Naive T Cells | Effector T Cells | Memory T Cells | ||
| Effector > Naive | ||||
| 0 | 54,848 | 4 | NM_008630 | Metallothionein 2 |
| 2 | 27,314 | 161 | NM_139198 | Placenta-specific 8 |
| 1 | 2,483 | 7 | NM_011340 | Serine or cysteine proteinase inhibitor clade |
| 0 | 1,837 | 66 | NM_001111099 | Cyclin-dependent kinase inhibitor 1A P21 |
| 1 | 1,620 | 19 | NM_145158 | Elastin microfibril interfacer 2 |
| 0 | 1,354 | 5 | NM_013542 | Granzyme B |
| 1 | 1,100 | 185 | NM_008519 | Leukotriene B4 receptor 1 |
| 5 | 6,117 | 7 | NM_009375 | Thyroglobulin |
| 1 | 931 | 5 | NM_133662 | Immediate early response 3 |
| 1 | 904 | 1 | NM_053095 | IL 24 |
| 0 | 895 | 20 | NM_021397 | Repressor of GATA |
| 2 | 1,461 | 17 | NM_007796 | CTL-associated protein 2 |
| 7 | 5,661 | 3819 | NM_026820 | IFN-induced transmembrane protein 1 |
| 11 | 7,979 | 94 | NM_010370 | Granzyme A |
| 0 | 713 | 4 | NM_001080815 | Gastric inhibitory polypeptide receptor |
| 0 | 543 | 21 | NM_008147 | gp49 A |
| 1 | 448 | 9 | NM_133720 | Cysteinyl leukotriene receptor 2 |
| 2 | 879 | 3 | NM_009150 | Selenium binding protein 1 |
| 50 | 22,626 | 82 | NM_011401 | Solute carrier family 2 facilitated glucose |
| 0 | 453 | 2 | NM_147776 | von Willebrand factor A domain–related protein |
| 3 | 1,202 | 81 | NM_011498 | Basic helix-loop-helix domain containing class |
| 2 | 724 | 0 | NM_008156 | GPI specific |
| 0 | 348 | 1 | NM_178241 | IL-8 receptor α |
| 63 | 21,938 | 26 | NM_013602 | Metallothionein 1 |
| 39 | 13,419 | 53 | NM_001077508 | TNF receptor superfamily |
| 1 | 299 | 38 | NM_008337 | IFN γ |
| 0 | 326 | 4 | NM_001004174 | Hypothetical protein LOC433470 |
| 0 | 325 | 0 | NM_207279 | Phosphatidylinositol-specific phospholipase C X |
| 0 | 322 | 21 | NM_013532 | Leukocyte Ig-like receptor |
| 0 | 319 | 0 | NM_009137 | Chemokine C-C motif ligand 22 |
| Effector < Naive | ||||
| 1517 | 0 | 159 | NM_009777 | Complement component 1 q subcomponent, B chain |
| 665 | 0 | 93 | NM_007574 | Complement component 1 q subcomponent, C chain |
| 590 | 0 | 39 | NM_007572 | Complement component 1 q subcomponent, A chain |
| 426 | 0 | 43 | NM_001083955 | Hemoglobin α adult chain 2 |
| 407 | 0 | 384 | NM_011703 | Vasoactive intestinal peptide receptor 1 |
| 3535 | 10 | 1,617 | NM_008052 | Deltex 1 homolog |
| 2037 | 7 | 121 | NM_001042605 | CD74 Ag isoform 1 |
| 306 | 0 | 4 | NM_019577 | Chemokine C-C motif ligand 24 |
| 289 | 0 | 14 | NM_007995 | Ficolin A |
| 313 | 1 | 13 | NM_001080934 | Solute carrier family 16 monocarboxylic acid |
| 219 | 0 | 5 | NM_001037859 | Colony stimulating factor 1 receptor |
| 178 | 0 | 139 | NM_033596 | Cistone cluster 2 H4 |
| 146 | 1 | 14 | NM_011414 | Secretory leukocyte peptidase inhibitor |
| 387 | 3 | 302 | NM_013832 | RAS protein activator like 1 GAP1 like |
| 120 | 0 | 19 | NM_133209 | Paired immunoglobulin-like type 2 receptor β |
| 117 | 0 | 9 | NM_008220 | Hemoglobin β adult major chain |
| 96 | 1 | 33 | NM_025806 | Hypothetical protein LOC66857 |
| 78 | 0 | 102 | NM_145227 | 2′-5′ oligoadenylate synthetase 2 |
| 78 | 0 | 163 | NM_178185 | Histone cluster 1 H2ao |
| 78 | 0 | 283 | NM_001033813 | Hypothetical protein LOC619310 |
| 85 | 1 | 7 | NM_008076 | γ-aminobutyric acid GABA-C receptor |
| 74 | 0 | 3 | NM_177686 | C-type lectin domain family 12 member a |
| 79 | 1 | 3 | NM_016704 | Complement component 6 |
| 71 | 1 | 6 | NM_009913 | Chemokine C-C motif receptor 9 |
| 64 | 0 | 11 | NM_138673 | Stabilin-2 |
| 64 | 0 | 9 | NM_001024932 | Paired immunoglobulin-like type 2 receptor β 2 |
| 69 | 1 | 5 | NM_011518 | Spleen tyrosine kinase |
| 523 | 9 | 28 | NM_009525 | Wingless-related MMTV integration site 5B |
| 59 | 0 | 4 | NM_009721 | Na+/K+ -ATPase β 1 subunit |
| 1615 | 28 | 734 | NM_010494 | ICAM 2 |
| Memory > Naive | ||||
| 7 | 5,661 | 3819 | NM_026820 | IFN-induced transmembrane protein 1 |
| 2 | 13 | 931 | NM_001099217 | Lymphocyte Ag 6 complex locus C2 |
| 15 | 59 | 3884 | NM_010741 | Lymphocyte Ag 6 complex locus C |
| 1 | 1,100 | 185 | NM_008519 | Leukotriene B4 receptor 1 |
| 2 | 122 | 360 | NM_015789 | Dickkopf-like 1 |
| 1 | 5 | 163 | NM_010553 | IL 18 receptor accessory protein |
| 0 | 309 | 179 | NM_031395 | Synaptotagmin-like 3 isoform a |
| 1 | 2 | 146 | NM_009915 | Chemokine C-C motif receptor 2 |
| 12 | 641 | 1,661 | NM_011313 | S100 calcium binding protein A6 calcyclin |
| 0 | 73 | 129 | NM_177716 | Hypothetical protein LOC239650 |
| 23 | 4,403 | 2,963 | NM_030694 | IFN-induced transmembrane protein 2 |
| 209 | 317 | 22,679 | NM_013653 | Chemokine C-C motif ligand 5 |
| 1 | 114 | 88 | NM_146064 | Acyl-CoA:cholesterol acyltransferase 2 |
| 1 | 3 | 84 | NM_133643 | EDAR ectodysplasin-A receptor–associated death |
| 2 | 27,314 | 161 | NM_139198 | Placenta-specific 8 |
| 3 | 16 | 224 | NM_013599 | Matrix metallopeptidase 9 |
| 1 | 53 | 70 | NM_030712 | Chemokine C-X-C motif receptor 6 |
| 4 | 72 | 268 | NM_011311 | S100 calcium binding protein A4 |
| 3 | 140 | 186 | NM_019507 | T-box 21 |
| 4 | 1,051 | 238 | NM_024253 | NK cell group 7 sequence |
| 0 | 1,837 | 66 | NM_001111099 | Cyclin-dependent kinase inhibitor 1A P21 |
| 1 | 4 | 59 | NM_016685 | Cartilage oligomeric matrix protein |
| 12 | 34 | 815 | NM_009910 | Chemokine C-X-C motif receptor 3 |
| 1 | 0 | 50 | NM_016958 | Keratin 14 |
| 1 | 41 | 44 | NM_008967 | PG I receptor IP |
| 132 | 729 | 5,823 | NM_001013384 | Podocan-like 1 |
| 0 | 31 | 43 | NM_010177 | Fas ligand TNF superfamily member 6 |
| 1 | 299 | 38 | NM_008337 | IFN γ |
| 1 | 1 | 37 | NM_010730 | Annexin A1 |
| 1 | 4 | 36 | NM_018734 | Guanylate nucleotide binding protein 4 |
| Naive > Memory | ||||
| 817 | 114 | 8 | NM_207231 | ADP-ribosylation-like factor 12 protein |
| 82 | 37 | 1 | NM_175274 | Tweety 3 |
| 306 | 0 | 4 | NM_019577 | Chemokine C-C motif ligand 24 |
| 75 | 74 | 0 | NM_010358 | Gst μ 1 |
| 61 | 52 | 1 | NM_011129 | Septin 4 |
| 53 | 63 | 1 | NM_027406 | Aldehyde dehydrogenase 1 family member l1 |
| 51 | 1 | 1 | NM_029162 | Zinc finger protein 509 |
| 51 | 0 | 1 | NM_008694 | Neutrophilic granule protein |
| 51 | 1 | 1 | NM_153510 | Paired immunoglobulin-like type 2 receptor α |
| 51 | 24 | 1 | NM_007405 | Adenylate cyclase 6 |
| 48 | 37 | 1 | NM_011984 | Homer homolog 3 |
| 148 | 5 | 3 | NM_009238 | SRY-box containing gene 4 |
| 46 | 12 | 1 | NM_013569 | Voltage-gated potassium channel subfamily H, |
| 44 | 10 | 1 | NM_026629 | Hypothetical protein LOC68235 |
| 43 | 25 | 1 | NM_011692 | Von Hippel-Lindau binding protein 1 |
| 219 | 0 | 5 | NM_001037859 | Colony stimulating factor 1 receptor |
| 115 | 22 | 3 | NM_008538 | Myristoylated alanine rich protein kinase C |
| 36 | 22 | 1 | NM_177758 | Zinc finger and SCAN domains 20 |
| 36 | 0 | 1 | NM_013612 | Solute carrier family 11 proton-coupled |
| 36 | 7 | 1 | NM_009223 | Stannin |
| 72 | 18 | 2 | NM_001033929 | Threonine synthase-like 2 |
| 36 | 53 | 0 | NM_011232 | RAD1 homolog |
| 94 | 18 | 3 | NM_011639 | Thyroid receptor-interacting protein 6 |
| 30 | 4 | 1 | NM_133921 | Ovarian zinc finger protein |
| 30 | 110 | 1 | NM_020006 | CDC42 effector protein Rho GTPase binding 4 |
| 33 | 16 | 0 | NM_009372 | TG-interacting factor |
| 29 | 1 | 1 | NM_013667 | Solute carrier family 22 member 2 |
| 28 | 14 | 1 | NM_030557 | Myoneurin |
| 177 | 25 | 6 | NM_001081127 | A disintegrin-like and metallopeptidase |
| 31 | 103 | 0 | NM_033612 | Elastase 1 pancreatic |
The 30 genes with the largest relative differences between effector and naive cells and between memory and naive cells are listed. The total number of tags from naive (3,382,975), effector (2,790,122), and memory (3,179,174) cells was normalized to 3,000,000.