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. 2013 Mar 24;2013:282707. doi: 10.1155/2013/282707

Table 4.

Subgroups and sensitivity analysis on ECG outcomes.

Group Number of
RCTs
Number of
participants
OR Wilcoxon
test
95% CI Z P (eff) I 2 χ 2 P (het)
M score ≤3 21 1995 2.47 W = 149 1.79, 3.41 5.53 <0.0001 52% 0.28 0.0025
>3 17 1709 2.71 P = 0.3945 2.17, 3.39 8.77 <0.0001 0% 0 0.9136
Sample size <93 23 1734 2.42 W = 127 1.93, 3.02 7.72 <0.0001 0% 0 0.9776
≥93 15 1970 2.86 P = 0.1789 1.94, 4.21 5.33 <0.0001 67% 0.37 0.0002
Number of authors 1 19 1872 2.30 W = 140 1.72, 3.08 5.65 <0.0001 41% 0.16 0.0358
>1 19 1832 2.98 P = 0.2428 2.34, 3.80 8.81 <0.0001 13% 0.04 0.4435
Publication year ≤2008 15 1268 2.49 W = 200 1.94, 3.20 7.17 <0.0001 0% 0 0.9538
>2008 23 2436 2.68 P = 0.4200 1.99, 3.61 6.47 <0.0001 52% 0.26 0.0025
Trial date report Reported 31 3069 2.43 W = 57 1.97, 3.00 8.29 <0.0001 34% 0.12 0.0511
Not reported 7 635 3.67 P = 0.0548 2.36, 5.70 5.79 <0.0001 8% 0.03 0.5363
Baseline
comparison
Reported 34 3318 2.64 W = 85 2.14, 3.24 9.20 <0.0001 35% 0.12 0.0513
Not reported 4 386 2.29 P = 0.4325 1.25, 4.19 2.68 0.0074 23% 0.09 0.2200
Adverse
events
Reported 19 1955 2.67 W = 192 2.16, 3.30 9.14 <0.0001 0% 0 0.8792
Not reported 19 1749 2.54 P = 0.7480 1.80, 3.59 5.28 <0.0001 54% 0.31 0.0020
Follow-up
period (day)
≤14 27 2528 2.83 W = 129 2.34, 3.42 10.67 <0.0001 2% 0 0.7120
>14 11 1176 2.21 P = 0.5407 1.37, 3.57 3.27 <0.0001 65% 0.39 0.0024
GXN daily 6–200 mL 38 3704 2.59 W = 707.5 2.14, 3.15 9.68 <0.0001 32% 0.11 0.0539
dosage (mL) 6–30 mL 37 3648 2.58 P = 0.9662 2.12, 3.14 9.45 <0.0001 33% 0.1175 0.0448
GXN daily <20 4 352 1.89 χ 2 = 3.4288, 1.00, 3.55 1.96 0.0497 27% 0.1148 0.2425
dosage (mL) 20 24 2324 2.80 df = 2 2.14, 3.66 7.51 <0.0001 43% 0.1820 0.0246
>20 10 1028 2.53 P = 0.1801 1.85, 3.46 5.81 <0.0001 14% 0.0365 0.5413
Types of angina Stable 4 374 3.03 χ 2 = 0.7010 1.80, 5.09 4.18 <0.0001 0% 0 0.6688
Unstable 16 1676 2.48 df = 2 1.95, 3.15 7.42 <0.0001 10% 0.02 0.2332
Angina 18 1654 2.60 P = 0.7043 1.87, 3.61 5.68 <0.0001 46% 0.22 0.0191
Improvement >50% 38 3704 2.59 W = 1050 2.14, 3.15 9.68 <0.0001 32% 0.11 0.0539
>80% 38 3704 1.84 P < 0.0001 1.59, 2.14 8.06 <0.0001 0% 0 0.8367
GXN 1 3 188 3.15 χ 2 = 1.6604 1.71, 5.81 3.68 0.0002 0% 0 0.9202
GXN + CG 2 29 2963 2.68 df = 2 2.10, 3.41 7.98 <0.0001 42% 0.17 0.0157
GXN + CG + additional 3 6 553 2.09 P = 0.4360 1.45, 3.01 3.94 <0.0001 0% 0 0.6382

CI is confidence interval; Z and P (eff) are statistical terms for evaluating overall effect; I 2, χ 2, and P (het) are statistical terms for assessing heterogeneity among studies.