Table 4.
Group | Number of RCTs |
Number of participants |
OR | Wilcoxon test |
95% CI | Z | P (eff) | I 2 | χ 2 | P (het) | |
---|---|---|---|---|---|---|---|---|---|---|---|
M score | ≤3 | 21 | 1995 | 2.47 | W = 149 | 1.79, 3.41 | 5.53 | <0.0001 | 52% | 0.28 | 0.0025 |
>3 | 17 | 1709 | 2.71 | P = 0.3945 | 2.17, 3.39 | 8.77 | <0.0001 | 0% | 0 | 0.9136 | |
Sample size | <93 | 23 | 1734 | 2.42 | W = 127 | 1.93, 3.02 | 7.72 | <0.0001 | 0% | 0 | 0.9776 |
≥93 | 15 | 1970 | 2.86 | P = 0.1789 | 1.94, 4.21 | 5.33 | <0.0001 | 67% | 0.37 | 0.0002 | |
Number of authors | 1 | 19 | 1872 | 2.30 | W = 140 | 1.72, 3.08 | 5.65 | <0.0001 | 41% | 0.16 | 0.0358 |
>1 | 19 | 1832 | 2.98 | P = 0.2428 | 2.34, 3.80 | 8.81 | <0.0001 | 13% | 0.04 | 0.4435 | |
Publication year | ≤2008 | 15 | 1268 | 2.49 | W = 200 | 1.94, 3.20 | 7.17 | <0.0001 | 0% | 0 | 0.9538 |
>2008 | 23 | 2436 | 2.68 | P = 0.4200 | 1.99, 3.61 | 6.47 | <0.0001 | 52% | 0.26 | 0.0025 | |
Trial date report | Reported | 31 | 3069 | 2.43 | W = 57 | 1.97, 3.00 | 8.29 | <0.0001 | 34% | 0.12 | 0.0511 |
Not reported | 7 | 635 | 3.67 | P = 0.0548 | 2.36, 5.70 | 5.79 | <0.0001 | 8% | 0.03 | 0.5363 | |
Baseline comparison |
Reported | 34 | 3318 | 2.64 | W = 85 | 2.14, 3.24 | 9.20 | <0.0001 | 35% | 0.12 | 0.0513 |
Not reported | 4 | 386 | 2.29 | P = 0.4325 | 1.25, 4.19 | 2.68 | 0.0074 | 23% | 0.09 | 0.2200 | |
Adverse events |
Reported | 19 | 1955 | 2.67 | W = 192 | 2.16, 3.30 | 9.14 | <0.0001 | 0% | 0 | 0.8792 |
Not reported | 19 | 1749 | 2.54 | P = 0.7480 | 1.80, 3.59 | 5.28 | <0.0001 | 54% | 0.31 | 0.0020 | |
Follow-up period (day) |
≤14 | 27 | 2528 | 2.83 | W = 129 | 2.34, 3.42 | 10.67 | <0.0001 | 2% | 0 | 0.7120 |
>14 | 11 | 1176 | 2.21 | P = 0.5407 | 1.37, 3.57 | 3.27 | <0.0001 | 65% | 0.39 | 0.0024 | |
GXN daily | 6–200 mL | 38 | 3704 | 2.59 | W = 707.5 | 2.14, 3.15 | 9.68 | <0.0001 | 32% | 0.11 | 0.0539 |
dosage (mL) | 6–30 mL | 37 | 3648 | 2.58 | P = 0.9662 | 2.12, 3.14 | 9.45 | <0.0001 | 33% | 0.1175 | 0.0448 |
GXN daily | <20 | 4 | 352 | 1.89 | χ 2 = 3.4288, | 1.00, 3.55 | 1.96 | 0.0497 | 27% | 0.1148 | 0.2425 |
dosage (mL) | 20 | 24 | 2324 | 2.80 | df = 2 | 2.14, 3.66 | 7.51 | <0.0001 | 43% | 0.1820 | 0.0246 |
>20 | 10 | 1028 | 2.53 | P = 0.1801 | 1.85, 3.46 | 5.81 | <0.0001 | 14% | 0.0365 | 0.5413 | |
Types of angina | Stable | 4 | 374 | 3.03 | χ 2 = 0.7010 | 1.80, 5.09 | 4.18 | <0.0001 | 0% | 0 | 0.6688 |
Unstable | 16 | 1676 | 2.48 | df = 2 | 1.95, 3.15 | 7.42 | <0.0001 | 10% | 0.02 | 0.2332 | |
Angina | 18 | 1654 | 2.60 | P = 0.7043 | 1.87, 3.61 | 5.68 | <0.0001 | 46% | 0.22 | 0.0191 | |
Improvement | >50% | 38 | 3704 | 2.59 | W = 1050 | 2.14, 3.15 | 9.68 | <0.0001 | 32% | 0.11 | 0.0539 |
>80% | 38 | 3704 | 1.84 | P < 0.0001 | 1.59, 2.14 | 8.06 | <0.0001 | 0% | 0 | 0.8367 | |
GXN | 1 | 3 | 188 | 3.15 | χ 2 = 1.6604 | 1.71, 5.81 | 3.68 | 0.0002 | 0% | 0 | 0.9202 |
GXN + CG | 2 | 29 | 2963 | 2.68 | df = 2 | 2.10, 3.41 | 7.98 | <0.0001 | 42% | 0.17 | 0.0157 |
GXN + CG + additional | 3 | 6 | 553 | 2.09 | P = 0.4360 | 1.45, 3.01 | 3.94 | <0.0001 | 0% | 0 | 0.6382 |
CI is confidence interval; Z and P (eff) are statistical terms for evaluating overall effect; I 2, χ 2, and P (het) are statistical terms for assessing heterogeneity among studies.