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. 2013 Mar 24;2013:616241. doi: 10.1155/2013/616241

Figure 3.

Figure 3

Inhibition of edema by the denatured NNAV in AIA rats. AIA rats were orally administrated once daily for 5 days before injection of CFA ((a), (c)) or from the 11th day to the 28th day after injection of CFA ((b), (d)) with the denatured NNAV (30, 90, 270 μg/kg), the native NNAV (90 μg/kg), or TWP (15 mg/kg). The volume of right hindpaw was measured using the method of water displacement. Changes in the circumference of ankle joint were determined with a flexible tape. ((a), (c)) and ((b), (d)) represented pretreatment protocol and posttreatment protocol, respectively. Data represent mean ± SD (n = 8). ### P < 0.001 compared with normal control group, *P < 0.05, **P < 0.01 compared with untreated arthritis group; † P < 0.05 denatured NNAV (270 μg/kg) versus TWP (15 mg/kg); Δ P < 0.05 denatured NNAV (90 μg/kg) versus native NNAV (90 μg/kg).