Table 2.
—The Relationship Between Lung Cancer and HIV Infection
| Study | Study Duration | Location | SIR | 95% CI |
| Grulich et al29 | 1980-1993 | Australia | 3.8 | 1.39-8.29 |
| Cooksley et al30 | 1975-1994 | Texas | 0.7 | 0.4-1.1 |
| Gallagher et al31 | 1981-1994 | New York | 3.3 | 2.86-3.75 |
| Parker et al13 | 1990-1995 | Texas | 6.5 | 4.5-8.9 |
| Frisch et al8 | 1978-1996 | 11 US areas | 4.5 | 4.2-4.8 |
| 1978-1996 | … | 2.8 | 2.4-3.1 | |
| Grulich et al29 | 1985-1999 | Australia | 1.44 | 0.84-2.30 |
| Herida et al32 | 1996-1999 (men) | France | 2.12 | 1.67-2.65 |
| 1992-1995 (men) | … | 1.13 | 0.71-1.72 | |
| 1996-1999 (women) | … | 6.59 | 3.40-11.52 | |
| 1992-1995 (women) | … | 1.08 | 0.01-5.98 | |
| Hessol et al33 | 1990-2000 | San Francisco, CA | 2.6 | 2.1-3.2 |
| Engels et al3 | 1980-1989 | 11 US regions | 2.5 | 1.9-3.3 |
| 1990-1995 | … | 3.3 | 2.9-3.8 | |
| 1996-2002 | … | 2.6 | 2.1-3.1 | |
| Bower et al15 | 1986-1996 | England | 0.8 | 0.2-1.4 |
| 1997-2002 | … | 6.7 | 3.5-9.9 | |
| Engels et al34 | 1991-2002 | Multiple US areas | 2.6 | 2.1-3.1 |
| Clifford et al35 | 1985-2003 | Switzerland | 3.2 | 1.7-5.4 |
| Patel et al5 | 1992-1995 | 13 US areas | SRR = 3.5 | 2.5-4.9 |
| 1996-1999 | … | SRR = 3.8 | 2.8-5.0 | |
| 2000-2003 | … | SRR = 3.6 | 2.8-4.6 | |
| Dal Maso et al36 | 1986-1996 | Italy | 2.1 | 1.2-3.3 |
| 1997-2004 | … | 4.1 | 2.9-5.5 | |
| Bedimo et al37 | 1997-2004 | United States | IRR = 2.0 | 1.8-2.2 |
| Long et al4 | 1996-2005 | Baltimore, MD | 5.5 | 3.7-8.0 |
| Guiguet et al28 | 1998-2006 (CD4 count > 500) | France | RR = 1.0 | … |
| 1998-2006 (CD4 count 350-499) | … | RR = 2.2 | 1.3-3.6 | |
| Powles et al6 | 1983-1995 | Europe | 0 | 0.00-1.52 |
| 1996-2001 | … | 3.1 | 1.34-6.11 | |
| 2002-2007 | … | 2.37 | 1.14-4.36 | |
| Silverberg et al38 | 1996-2007 | California | RR = 1.9 | 1.4-2.5 |
| Shiels et al39 | 1996-2007 | Multiple US areas | 3 | 2.8-3.2 |
| Engsig et al25 | 1995-2009 | Denmark | IRR = 2.38 | 1.61-3.53 |
| Grulich et al29, a | 1978-2003 | Meta-analysis | 2.72 | 1.91-3.87 |
| Shiels et al9, a | 1981-2005 | Meta-analysis | 2.6 | 2.1-3.1 |
| Chaturvedi et al40, b | 1980-2002 (−60 to +60 mo AIDS onset) | 11 US regions | 3.8 | 3.6-4.1 |
| 1980-2002 (−6 to +3 mo AIDS onset) | … | 10.5 | 9.7-11.4 | |
| Kirk et al41, b | 1988-2003 | Baltimore, MD | HR = 3.6 (risk of death) | 1.6-7.9 |
| Engels et al18, b | 1989-2003 | Baltimore, MD | SIR = 2.5 | 1.6-3.5 |
| Shiels et al42, b | 1988-2007 | Baltimore, MD | HR = 2.3 (risk of lung cancer) | 1.1-5.1 |
| … | HR = 3.8 (risk of death) | 0.92-15 |
HR = hazard ratio; IRR = incidence rate ratio; RR = relative risk; SIR = standardized incidence rate; SRR = standardized rate ratio.
a
Meta-analysis.
b
Adjusted for smoking.