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COX-2, Gordian knot or Achilles heel? (A) Physiological processes with significant COX-2 involvement. (B) COX-2 silencing changes the metabolic profile of breast cancer cells to a less aggressive phenotype. (C) COX-2 silencing reduces the invasiveness of breast cancer cell. (D) COX-2 silencing abolishes the extrapulmonary colonization of metastatic breast cancer cells. (E) Sites of primary tumors with extensive COX-2 involvement.
