Figure. Distribution of cortical atrophy on MRI studies of Patients 1 and 2.
Patient 1 is a LRRK2 G2019S heterozygote and carries a clinical diagnosis of corticobasa syndrome. Patient 2 is a LRRK2 R793M heterozygote and carries a clinical diagnosis of primary progressive aphasia/frontotemporal dementia. Areas of relative atrophy compared to control groups of healthy seniors are shown in color (statistical threshold for display p < 0.001).