Table 3. Distribution of cortical atrophy on MRI studies of Patients 1 and 2.

		Coordinates
	Anatomic region (Brodmann area)	X	Y	Z	No. voxels	Z-score
Patient 1	Left superior parietal (7)	−34	−48	59	245	4.44
	Left medial frontal gyrus (11)	−2	36	−10	227	4.04
	Left mid frontal gyrus (6)	−16	7	59	132	4.02
	Left parahippocampal gyrus (19)	−28	−51	−3	194	3.70
	Left frontal gyrus (6)	−61	4	9	205	3.56
Patient 2	Right temporal fusiform gyrus (37)	28	−45	−11	14,106	6.50
	Right posterior cerebellar tonsil	44	−58	−39	796	6.11
	Right mid temporal gyrus (21)	65	−24	−7	2,175	5.55
	Right inferior parietal (40)	55	−56	43	948	5.15
	Left posterior cerebellar tonsil	−44	−62	−40	1,031	4.70
	Left temporal fusiform gyrus (37)	−32	−45	−10	668	4.26
	Left frontal gyrus (44)	−55	14	9	510	4.00

Patient 1 is a LRRK2 G2019S heterozygote and carries a clinical diagnosis of corticobasal syndrome. Patient 2 is a LRRK2 R793M heterozygote and carries a clinical diagnosis of primary progressive aphasia/frontotemporal dementia. Z-score is based on comparison to healthy controls as described previously.¹⁹