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. Author manuscript; available in PMC: 2013 Apr 8.
Published in final edited form as: Cancer. 2010 Feb 1;116(3):544–573. doi: 10.1002/cncr.24760

Table 1.

SEER Cancer Incidence Rate Trends With Joinpoint Analyses (Up to 4 Joinpoints Allowed) for 1975–2006 for the Top 15 Cancers, by Sex, for All Racesa

Joinpoint analyses (1975–2006)b
Trend 1 Trend 2 Trend 3 Trend 4 Trend 5 AAPCf
Sex/cancer site or type Years APCe Years APCe Years APCe Years APCe Years APCe 1997–2006 2002–2006
All sitesc
 Both sexes 1975–1989 1.2g 1989–1992 2.8g 1992–1995 −2.4 1995–1999 1.0 1999–2006 −1.1g −0.6h −1.1h
  (Delay-adjusted) 1975–1989 1.2g 1989–1992 2.8 1992–1995 −2.4 1995–1999 0.9 1999–2006 −0.7g −0.4h −0.7h
 Males 1975–1989 1.3g 1989–1992 5.1g 1992–1995 −4.8g 1995–2001 0.3 2001–2006 −1.9g −0.9h −1.9h
  (Delay-adjusted) 1975–1989 1.3g 1989–1992 5.2g 1992–1995 −4.9g 1995–2000 0.5 2000–2006 −1.3g −0.7h −1.3h
 Females 1975–1979 −0.3 1979–1987 1.6g 1987–1995 0.1 1995–1998 1.5 1998–2006 −0.8g −0.5h −0.8h
  (Delay-adjusted) 1975–1979 −0.3 1979–1987 1.6g 1987–1995 0.1 1995–1998 1.4 1998–2006 −0.5g −0.3 −0.5h
Top 15 cancers for malesd
 Prostate 1975–1988 2.6g 1988–1992 16.4g 1992–1995 −11.4g 1995–2001 1.8 2001–2006 −3.4g −1.1 −3.4h
  (Delay-adjusted) 1975–1988 2.6g 1988–1992 16.5g 1992–1995 −11.7g 1995–2000 2.4 2000–2006 −2.4g −0.8 −2.4h
 Lung and bronchus 1975–1982 1.4g 1982–1991 −0.4 1991–2006 −1.9g −1.9h −1.9h
  (Delay-adjusted) 1975–1982 1.4g 1982–1991 −0.4 1991–2006 −1.8g −1.8h −1.8h
 Colon and rectum 1975–1986 1.1g 1986–1995 −2.1g 1995–1998 1.1 1998–2004 −2.6g 2004–2006 −5.7g −2.9h −4.2h
  (Delay-adjusted) 1975–1985 1.1g 1985–1991 −1.2g 1991–1995 −3.2g 1995–1998 2.1 1998–2006 −3.0g −2.5h −3.0h
 Urinary bladder 1975–1987 1.0g 1987–1996 −0.5 1996–1999 1.8 1999–2006 −0.8g −0.2 −0.8h
  (Delay-adjusted) 1975–1987 0.9g 1987–2006 0.0 0.0 0.0
 Melanoma of the skin 1975–1986 5.5g 1986–2006 2.9g 2.9h 2.9h
  (Delay-adjusted) 1975–1986 5.4g 1986–2006 3.1g 3.1h 3.1h
 Non-Hodgkin lymphoma 1975–1991 4.3g 1991–2006 0.1 0.1 0.1
  (Delay-adjusted) 1975–1991 4.2g 1991–2006 0.3 0.3 0.3
 Kidney and renal pelvis 1975–2006 1.7g 1.7h 1.7h
  (Delay-adjusted) 1975–2006 1.8g 1.8h 1.8h
 Leukemia 1975–2004 −0.1 2004–2006 −6.6 −1.6h −3.4
  (Delay-adjusted) 1975–2006 0.1g 0.1h 0.1h
 Oral cavity and pharynx 1975–1983 −0.2 1983–2006 −1.4g −1.4h −1.4h
  (Delay-adjusted) 1975–2006 −1.2g −1.2h −1.2h
 Pancreas 1975–1993 −0.9g 1993–2006 0.3 0.3 0.3
  (Delay-adjusted) 1975–1981 −1.8g 1981–1985 1.1 1985–1990 −2.1 1990–2003 0.1 2003–2006 2.5 0.9 1.9
 Stomach 1975–1988 −1.2g 1988–2006 −2.0g −2.0h −2.0h
  (Delay-adjusted) 1975–1988 −1.2g 1988–2006 −2.0g −2.0h −2.0h
 Liver and intrahepatic bile duct 1975–1986 2.1g 1986–1996 4.9g 1996–2006 2.6g 2.6h 2.6h
  (Delay-adjusted) 1975–2006 3.6g 3.6h 3.6h
 Esophagus 1975–2006 0.7g 0.7h 0.7h
  (Delay-adjusted) 1975–2006 0.7g 0.7h 0.7h
 Brain and other nervous system 1975–1991 1.1g 1991–2006 −0.7g −0.7h −0.7h
  (Delay-adjusted) 1975–1991 1.0g 1991–2006 −0.5g −0.5h −0.5h
 Myeloma 1975–2002 0.8g 2002–2006 −3.0 −0.9 −3.0
  (Delay-adjusted) 1975–2006 0.7g 0.7h 0.7h
Top 15 cancers for femalesd
 Breast 1975–1980 −0.5 1980–1987 4.0g 1987–1994 −0.2 1994–1999 1.6g 1999–2006 −2.2g −1.3h −2.2h
  (Delay-adjusted) 1975–1980 −0.5 1980–1987 4.0g 1987–1994 −0.1 1994–1999 1.6g 1999–2006 −2.0g −1.2h −2.0h
 Lung and bronchus 1975–1982 5.5g 1982–1990 3.5g 1990–1998 1.0g 1998–2006 −0.1 0.0 −0.1
  (Delay-adjusted) 1975–1982 5.6g 1982–1991 3.4g 1991–2006 0.4g 0.4h 0.4h
 Colon and rectum 1975–1985 0.3 1985–1995 −1.9g 1995–1998 2.0 1998–2006 −2.4g −1.9h −2.4h
  (Delay-adjusted) 1975–1985 0.3 1985–1995 −1.8g 1995–1998 1.9 1998–2006 −2.2g −1.7h −2.2h
 Corpus and uterus, NOS 1975–1979 −6.0g 1979–1988 −1.7g 1988–1997 0.7g 1997–2006 −0.6g −0.6h −0.6h
  (Delay-adjusted) 1975–1979 −6.0g 1979–1988 −1.7g 1988–1997 0.7g 1997–2006 −0.5g −0.5h −0.5h
 Melanoma of the skin 1975–1980 5.6g 1980–2006 2.4g 2.4h 2.4h
  (Delay-adjusted) 1975–1981 5.7g 1981–1993 1.9g 1993–2006 3.0g 3.0h 3.0h
 Non-Hodgkin lymphoma 1975–1990 2.8g 1990–2004 1.2g 2004–2006 −2.5 0.3 −0.7
  (Delay-adjusted) 1975–1990 2.9g 1990–2006 1.1g 1.1h 1.1h
 Thyroid 1975–1977 6.5 1977–1980 −5.3 1980–1995 2.3g 1995–2006 6.0g 6.0h 6.0h
  (Delay-adjusted) 1975–1977 6.5 1977–1980 −5.3 1980–1995 2.3g 1995–2006 6.3g 6.3h 6.3h
 Ovaryc 1975–1985 0.1 1985–2001 −0.7g 2001–2006 −2.6g −1.8h −2.6h
  (Delay-adjusted)c 1975–1985 0.1 1985–2001 −0.7g 2001–2006 −2.1g −1.5h −2.1h
 Pancreas 1975–1984 1.5g 1984–1995 −0.6 1995–2006 0.6g 0.6h 0.6h
  (Delay-adjusted) 1975–1984 1.3g 1984–2000 −0.3 2000–2006 1.7g 1.0h 1.7h
 Leukemia 1975–2006 0.0 0.0 0.0
  (Delay-adjusted) 1975–2006 0.3g 0.3h 0.3h
 Kidney and renal pelvis 1975–2006 2.3g 2.3h 2.3h
  (Delay-adjusted) 1975–2006 2.4g 2.4h 2.4h
 Urinary bladder 1975–2003 0.2g 2003–2006 −2.3 −0.6 −1.7
  (Delay-adjusted) 1975–2006 0.2g 0.2h 0.2h
 Cervix uteri 1975–1981 −4.6g 1981–1996 −1.1g 1996–2006 −3.6g −3.6h −3.6h
  (Delay-adjusted) 1975–1981 −4.6g 1981–1996 −1.1g 1996–2006 −3.5g −3.5h −3.5h
 Oral cavity and pharynx 1975–1980 2.6g 1980–2006 −1.0g −1.0h −1.0h
  (Delay-adjusted) 1975–1980 2.5 1980–2006 −0.9g −0.9h −0.9h
 Brain and other nervous system 1975–1987 1.6g 1987–2006 −0.3 −0.3 −0.3
  (Delay-adjusted) 1975–1987 1.6g 1987–2006 −0.1 −0.1 −0.1

SEER: Surveillance, Epidemiology and End Results; APC: annual percent change; NOS: not otherwise specified.

a

Source: SEER 9 areas covering about 10% of the U.S. population (Connecticut, Hawaii, Iowa, Utah, and New Mexico, and the metropolitan areas of San Francisco, Detroit, Atlanta, and Seattle-Puget Sound).

b

Joinpoint analyses with up to four joinpoints are based on rates per 100,000 persons and were age-adjusted to the 2000 U.S. standard population (19 age groups Census p25–1130). Joinpoint (JP) Regression Program, Version 3.3.1. April 2008, National Cancer Institute.

c

All sites excludes myelodysplastic syndromes and borderline tumors; ovary excludes borderline tumors.

d

The top 15 cancers were selected based on the sex-specific age-adjusted incidence rates for 2002–2006 for all races combined and are listed in rank order.

e

APC is based on rates that were age-adjusted to the 2000 U.S. standard population (19 age groups Census p25–1130).

f

The AAPC is the Average Annual Percent Change and is a weighted average of the APCs calculated by Joinpoint.

g

APC is statistically significantly different from zero (2-sided P < .05).

h

AAPC is statistically significantly different from zero.