Table III.
Adjusted odds ratios (New York and New Jersey samples combined) for CGG repeat length at the FMR1 locus for cases (trisomy loss) versus controls (non-trisomy chromosomally abnormal loss, chromosomally normal loss, live birth): (1) for the total sample; (2) for white non-Hispanic women.
| Adjusted odds ratio (95% CI) for CGG repeat length: trisomy cases versus each comparison group |
|||
|---|---|---|---|
| Non-trisomy abnormal loss | Chromosomally normal loss | Birth | |
| (1) Total samplea | |||
| Biallelic mean | |||
| 19.0–22.0 | 0.3 (0.1, 1.0) | 0.8 (0.2, 3.7) | 0.4 (0.1, 1.2) |
| 22.5–26.0 | 0.7 (0.3, 1.5) | 1.2 (0.6, 2.5) | 0.7 (0.5, 1.2) |
| 26.5–30.0 | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 30.5–35.0 | 0.4 (0.2, 0.8) | 0.8 (0.4, 1.4) | 0.9 (0.6, 1.3) |
| 35.5–59.5 | 1.6 (0.5, 5.3) | 3.8 (0.96, 15.4) | 1.5 (0.7, 3.1) |
| Genotypic mean: 35.5 to <58.0 (versus 26.5 to <30.5) | 1.5 (0.4, 5.2) | 1.8 (0.6, 5.7) | 1.5 (0.8, 3.1) |
| Allele 2: 35–89 (versus 30) | 1.4 (0.6, 3.2) | 1.3 (0.6, 2.8) | 1.3 (0.8, 2.1) |
| Allele 1: 9–19 (versus 23–29) | 0.3 (0.1, 1.3) | 0.6 (0.1, 2.9) | 0.5 (0.2, 1.5) |
| (2) White, non-Hispanic womenb | |||
| Biallelic mean | |||
| 19.0–22.0 | 0.3 (0.1, 1.3) | 1.2 (0.2, 6.9) | 0.5 (0.2, 1.6) |
| 22.5–26.0 | 0.7 (0.3, 1.7) | 1.2 (0.5, 2.6) | 0.7 (0.4, 1.2) |
| 26.5–30.0 | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| 30.5–35.0 | 0.5 (0.3, 1.04) | 0.7 (0.4, 1.4) | 0.9 (0.6, 1.5) |
| 35.5–59.5 | 2.1 (0.5, 8.2) | 3.7 (0.9, 15.7) | 1.9 (0.9, 3.9) |
| Genotypic mean: 35.5 to <58.0 (versus 26.5 to <30.5) | 2.0 (0.5, 7.5) | 1.7 (0.5, 5.4) | 2.0 (0.96, 4.2) |
| Allele 2: 35–89 (versus 30) | 2.1 (0.8, 5.4) | 1.4 (0.6, 3.0) | 1.5 (0.9, 2.5) |
| Allele 1: 9–19 (versus 23–29) | 0.4 (0.1, 1.7) | 2.2 (0.2, 19.4) | 0.6 (0.2, 1.8) |
aOdds ratios from conditional maximum likelihood logistic regression. Analyses adjust by stratification for site (New York, New Jersey) and age in single years and by indicator variable for race (White non-Hispanic versus Other).
bOdds ratios from conditional maximum likelihood logistic regression. Analyses adjust by stratification for site (New York, New Jersey) and age in single years. Analyses of White, non-Hispanic women are based on 181 women with trisomy losses, 72 women with non-trisomy chromosomally abnormal losses, 82 women with chromosomally normal losses and 470 women with births.