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VEGFR-3 increases tumor formation and tumor growth in xenotransplant mouse model
| Cell line | Tumor incidence | Median tumor volume (mm3) | Estrogen pellet |
|---|---|---|---|
| MCF7-pcDNA3 | 0/11 (0%) | N/A* | No |
| MCF7-VEGFR-3 | 14/15 (93%) | 2153 ± 395 | No |
| MCF7-pcDNA3 | 5/5 (100%) | 239 ± 79 | Yes |
| MCF7-VEGFR-3 | 5/5 (100%) | 2589 ± 429** | Yes |
MCF7-pcDNA3 inoculated mice failed to develop tumors.
p < 0.005.
