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. Author manuscript; available in PMC: 2013 Apr 8.
Published in final edited form as: Glia. 2011 Feb 8;59(8):1155–1168. doi: 10.1002/glia.21142

Figure 3.

Figure 3

Schematic representation of the most common EGFR mutant alleles observed in cancer and gliomas. The amino acid numbering represented is for the EGFR mature protein without the 24-residue signal peptide. The 12 known intracellular tyrosine phosphorylation sites are indicated. LB, ligand binding domain; CR1/2, cysteine-rich domain. Only those point mutants found at a frequency of >2% in gliomas are indicated and can be found on the COSMIC website (http://www.sanger.ac.uk/genetics/CGP/cosmic/).