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. 2013 Apr 8;8(4):e60921. doi: 10.1371/journal.pone.0060921

Figure 2. Phagocytic capacity of cortical microglia is impaired in two mouse models of cerebral amyloidosis.

Figure 2

(A) Representative images (left) and microglial phagocytic index (in arbitrary units, a.u., right) of 9 month old APPPS1 mice and wildtype littermate controls (3 mice per genotype; p<0.001). Images show microglia (Iba-1, red), Aβ (4G8, blue) and fluorescent microspheres (green). Orthogonal views of z-stack images are shown in the bottom panel. (B) Representative images (left) and microglial phagocytic index of 20 month old APP23 and age-matched control mice (3 mice per genotype, p<0.001, right) are shown. Data are mean ± s.e.m, ***p<0.001. Scale bars: 10 µm.