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. 2013 Apr 8;8(4):e61125. doi: 10.1371/journal.pone.0061125

Figure 2. GATA3 reduces effectors in the TGFß1 pathway in MB-231 cells.

Figure 2

(A) Ingenuity network analysis of 231-Empty vs. 231-GATA3 cells. Genes that were differentially expressed in 231-Empty vs. 231-GATA3 cells (p<0.001, fold change >1.5) were input into Ingenuity Pathway analysis. One of the top networks identified demonstrated changes in several TGFß1 effectors. (B) Western blot of 231-Empty and 231-GATA3 cells validating changes in expression of Smad2, Smad3 and Smad1 between 231-Emtpy and 231-GATA3 cells.