Table 3. Hepatocanalicular transporter pathway.
| Genotypes/Alleles | Controls n (%) | Cases n (%) | p-value | OR (95% CI) |
| ABCG8 145G>C | ||||
| GG | 209 (95.0) | 206 (89.6) | − | 1 (reference) |
| GC+CC | 11 (5.0) | 24 (10.4) | 0.019 | 2.47 (1.16–5.25) |
| Ptrend | 0.031 | |||
| *MCS | 0.022 | |||
| G | 429 (97.5) | 436 (94.9) | − | 1 (reference) |
| C | 11 (2.5) | 24 (5.1) | 0.025 | 2.41 (1.12–5.22) |
| SLCO1B1 Exon4 C>A | ||||
| CC | 205 (93.2) | 200 (87.0) | − | 1 (reference) |
| CA+AA | 15 (6.8) | 30 (13.0) | 0.007 | 2.63 (1.30–5.29) |
| Ptrend | 0.028 | |||
| *MCS | 0.020 | |||
| C | 425 (96.6) | 430 (93.2) | − | 1 (reference) |
| A | 15 (3.4) | 30 (6.8) | 0.015 | 2.21 (1.16–4.21) |
| SLCO1B1 Ex6+40T>C | ||||
| TT | 212 (96.4) | 218 (94.8) | − | 1 (reference) |
| TC+CC | 8 (3.6) | 12 (5.2) | 0.422 | 1.46 (0.57–3.72) |
| Ptrend | 0.416 | |||
| *MCS | 0.298 | |||
| T | 432 (99.0) | 448 (98.7) | − | 1 (reference) |
| C | 8 (1.0) | 12 (1.3) | 0.850 | 1.08 (0.46–2.52) |
MCS = Monte Carlo Simulation; Significant values are in bold; For categorical data Cochrane Armitage trend test was used.