Table 6. Association of High-Order Interactions with GSD Risk by MDR Analysis.
| No. of interactingloci | Best Interaction Model | Testing Accuracy | #CVC | P for permutation Testing |
| 1 | ABCG8 145 G>C | 0.5156 | 7/10 | 0.0027 |
| 2 | ESR1 IVS1 351A>G ADRB3 -190T>C | 0.5784 | 10/10 | <0.001 |
| 3 | ESR1 IVS1-397C>T ESR1 IVS1 351A>G, ADRB3 -190T>C | 0.6050 | 8/10 | <0.001 |
| 4 | a ESR1 IVS1-397C>T, ESR1 IVS1 351A>G, ADRB3 -190T>CABCG8 145 G>C | 0.6212 | 10/10 | <0.001 |
#
CVC: Cross Validation Consistency.
a
The model with the maximum testing accuracy and maximum CVC cross was considered as the best model. The present study calculated, the best interaction model as the four-factor model including aESR1 IVS1-397C>T, ESR1 IVS1 351A>G, ADRB3-190T>C, ABCG8 145 G>C polymorphisms.