Table 1. Histopathological tumor grading in Control and MARKO mice.
| Mouse # | Genotype | Necrosis | Mitosis per 40X (field diameter 0.44 mm) | Grade |
| C424 | Control | Extensive | 8 | High |
| C589 | Control | Extensive | 5 | High |
| C745 | Control | None | 2 | Low |
| C951 | Control | None | 1 | Low |
| C756 | Control | Focal | 2 | Low |
| C764 | Control | None | 2 | Low |
| C779 | Control | None | 1 | Low |
| C786 | Control | Focal | 1 | Low |
| C410 | Control | Tumor was too small and was used up for RNA analysis | ||
| C299 | MARKO | None | 1 | Low |
| C472 | MARKO | Focal | 5 | High |
| C582 | MARKO | None | 1 | Low |
| C658 | MARKO | Focal | 4 | High |
| C775 | MARKO | Focal | 3 | Low |
| C777 | MARKO | Focal | 1 | Low |
| C755 | MARKO | Focal | 4 | High |
| C754 | MARKO | Tumor was too small and was used up for RNA analysis | ||
Mitotic count and presence/absence of necrosis were used as grading criteria in this study. Tumors with a low mitotic count (<4 hpf) and focal (<5%) or no necrosis correspond to low grade carcinoma while those with a high mitotic rate (≥4/5 hpf) and necrosis (>5%) are considered high grade. Low and high grade carcinomas were detected in both Control and MARKO groups.