Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Apr 8;8(4):e60425. doi: 10.1371/journal.pone.0060425

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Guzzetta, Kirschner

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Reproduction of endogenous reactivation. The simulation is performed by using the same inoculum of bacteria at initial times of primary infection years and keeping the same set of immune parameters fixed (specified in Table S1 in File S1). Green: clearance of infection; orange: LTBI followed by reactivation; red: primary active disease. The oscillations in reactivation curves are not perfectly overlapping, but difference in oscillation phase are not visible at this time scale. In the lower panel, black marks indicate the number of T-helper type 1 (Th1) cells at the peak of the acute phase, a proportion of which is used to generate circulating memory T cells according to Equation 1. The number of T cells for infection at age 0 is only displayed until the time at which both extracellular and intracellular Mtb are cleared, after which the simulation is terminated.

Inline graphic — Reproduction of endogenous reactivation. The simulation is performed by using the same inoculum of bacteria at initial times of primary infection years and keeping the same set of immune parameters fixed (specified in Table S1 in File S1). Green: clearance of infection; orange: LTBI followed by reactivation; red: primary active disease. The oscillations in reactivation curves are not perfectly overlapping, but difference in oscillation phase are not visible at this time scale. In the lower panel, black marks indicate the number of T-helper type 1 (Th1) cells at the peak of the acute phase, a proportion of which is used to generate circulating memory T cells according to Equation 1. The number of T cells for infection at age 0 is only displayed until the time at which both extracellular and intracellular Mtb are cleared, after which the simulation is terminated.