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. 2013 Apr 8;8(4):e60425. doi: 10.1371/journal.pone.0060425

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© 2013 Guzzetta, Kirschner

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — Outcomes of secondary infection for all possible combinations of time of primary infection and time of secondary infection (constraining ), sampled with a step of 2 years (hence the pixel-like appearance of the graphs). All graphs in the figure have the same y axis, whose label is reported in the leftmost graph only. All parameters of the immune models are kept fixed at the same baseline values (see Table S1 in File S1), and the aging rate is set to 0.05 years; The CD4+ specific immunogenic potential varies with the panels. Dark red: active disease; orange: LTBI followed by endogenous reactivation at some point of the host’s life; turquoise: clearance of primary infection.

Outcomes of secondary infection for all possible combinations of time of primary infection and time of secondary infection (constraining ), sampled with a step of 2 years (hence the pixel-like appearance of the graphs). All graphs in the figure have the same y axis, whose label is reported in the leftmost graph only. All parameters of the immune models are kept fixed at the same baseline values (see Table S1 in File S1), and the aging rate is set to 0.05 years; The CD4+ specific immunogenic potential varies with the panels. Dark red: active disease; orange: LTBI followed by endogenous reactivation at some point of the host’s life; turquoise: clearance of primary infection.