Table 1. HTRA1 mRNA expression levels in a cohort of 131 breast cancer patients.

Variable	N = 131a	HTRA1 Expression Medianb (IRc)	p
Age			0.271d
<50	23	48 (54)
>50	108	37 (51)
Menopausal status			0.337d
pre−/perimenopausal	28	45 (47)
postmenopausal	103	37 (56)
Lymph node status			0.439e
negative	52	41 (47)
1–3 lymph nodes	43	48 (63)
4–9 lymph nodes	11	34 (41)
>9 lymph nodes	6	19 (45)
Tumor stage (pT)			0.025 e
1	39	53 (58)
2	72	40 (49)
3+4	18	20 (26)
Grading			0.587d
1+2	49	45 (60)
3	46	30 (49)
Estrogen receptor			0.672d
negative	37	32 (65)
positive	91	43 (54)
Progesterone receptor			0.219d
negative	51	31 (56)
positive	77	45 (56)
Surgery			0.320d
breast conserving	38	47 (60)
mastectomy	93	32 (49)

^aDue to missing data the sum of values may be lower than 131.

^bMedian of relative HTRA1 mRNA expression values after normalization to glucose-6-phosphate-dehydrogenase (h-G6PDH) expression and adjustment to the sample with lowest HTRA1 expression.

^cIR: interquartile range.

^dMann-Whitney-U test.

^eKruskal-Wallis test.